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Search Results for " duplex dna "

6

Compounds

Cat No. Product Name Synonyms Targets
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T23133 Pentamidine Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T11118 Duocarmycin SA Others
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom...
T11338 Furamidine DB75,NSC 305831 Others
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28...
T81640 NSC15520
NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the he...
T37218 N-methyl Mesoporphyrin IX
N-methyl Mesoporphyrin IX is a widely used G-quadruplex DNA-specific fluorescent binder that effectively monitors Aβ fibrillation. N-methyl Mesoporphyrin IX is sensitive to G-quadruplex DNA and unreactive to duplex, trip...
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